The heterogeneous expression of tumor antigens within the primary tumor or its metastases, the modification of antigenic profile during the tumor progression, and the low levels of the antigen major histocompatibility complex proteins, as well as the low levels of other co stimulatory proteins necessary to generate a strong immune response can explain the low immunogenicity level of tumors buy generic lasix online Liu P, Leong T, Quam L, et al
